JSNM 1998 Akita, Japan

Measurement of Serum CA19-9 Tumor Marker levels by the new method and comparison with convention kit

K. Ahmed, T. Inoue, N. Oriuchi, M. Sarwar, S. Alyafei, H. Zhang, K. Endo.

Department of Nuclear Medicine, Gunma University School of Medicine, Japan.

MSW-113 monoclonal antibody was used in new CA19-9 kit. MS-113 recognizes sialyl-le like NS19-9, but its recognition epitope of the oligosaccharide is little biased to sialic acid residue. We examined the basic and the clinical usefulness of new developed CA19-9 kit (Dai Ichi R). The intra and interassay reproducibility was 3.80% and 7.90%, respectively. The mean recovery rate was close to 100%. There was no effect of dilution on CA19-9 serum values. The normal range of CA19-9 values in serum of 60 normal volunteers were 4.49-11.31. Although a significant correlation (Y=0.38X+10.16 r=0.80) was observed between this CA19-9 new kit and conventional kit. The measurement of serum CA19-9 was useful for evaluation of pathological function and seemed to be helpful in management of patients with malignancies.

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